Synonyms Chem
Indications Contraindications Use During Pregnancy and Breastfeeding Adverse Effects
Chloramphenicol is a synthetic broad-spectrum antibiotic used to treat
Antimicrobial Spectrum: Gram-positive: Streptococcus spp
For β-lactams, bacterial resistance can involve the enzymatic hydrolysis of the β-lactam bond within the β-lactam ring of the drug molecule
Use of chloramphenicol during pregnancy results in fetal drug levels almost as high as maternal levels
Trimethoprim is used in combination with the sulfa drug sulfamethoxazole to treat urinary tract infections, ear infections, and bronchitis
Pyrimethamine is a synthetic drug that inhibits a different enzyme in the folic acid production pathway and is often used in combination with sulfadoxine The next antibiotic manufactured by a fully synthetic route after the sulfa drugs was chloramphenicol, a natural product first isolated in 1947 from a culture of Streptomyces venezuelae by John Ehrlich and collaborators at Parke, Davis & Co
The drugs of choice for respiratory infections are extended-spectrum penicillins, cephalosporins, tetracyclines (especially doxycycline), trimethoprim-sulfa, chloramphenicol, fluoroquinolones, macrolides, and, for anaerobic infections, clindamycin or metronidazole
(H) A carbacephem
If a person has had an allergic reaction to Bactrim, Resprim or Septrin, there is no way of knowing whether the allergy was to sulfamethoxazole or to trimethoprim
b) chloramphenicol
Chloroquine F
Streptomycin D
norfloxacin (discontinued) ofloxacin
Chloramphenicol palmitate: Antibiotic General antibiotic therapy: 50 mg/kg q12h to q8h; IM, SC (Blackwells, 2011) 30-50 Time-dependent drugs include beta-lactams, cephalosporins, sulfa drugs, tetracyclines, and chloramphenicol
Aminoglycosides = End in “mycin/micin”
Pregnancy: Category C: Risk unknown